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Myricitrin Blocks Activation of NF-κB and MAPK Signaling Pathways to Protect Nigrostriatum Neuron in LPS-stimulated Mice

Myricitrin Blocks Activation of NF-κB and MAPK Signaling Pathways to Protect Nigrostriatum Neuron in LPS-stimulated Mice

Ying-Lin Yang, Man Liu, Xiao Cheng, Wei-Han Li, Shan-Shan Zhang, Yue-Hua Wang, Guan-Hua Du

J Neuroimmunol. 2019 Dec 15;337:577049.

PMID: 31526918

Abstract:

Myricitrin, a bioactive and natural flavonoids, is well known for its anti-inflammatory and antioxidant properties. However, the anti-neuroinflammation and possible mechanism has not been fully elucidated. Therefore, the present study was to investigate the possible mechanism of its neuroprotection and anti-neuroinflammation in the nigrostriatum of LPS-stimulated mice. The results showed that myricitrin improved neuron injury and raised the expressions of PSD-95 protein and TH protein in the nigrostriatum of LPS-stimulated mice. In addition, myricitrin decreased the production of pro-inflammatory factors including IL-1β, IL-6 and TNFα, decreased the level of chemokine MCP-1, and suppressed the expressions of COX-2 and iNOS. Meanwhile, myricitrin suppressed HMGB1, TLR4, and MyD88 expression in the nigrostriatum of LPS-stimulated mice. Furthermore, myricitrin inhibited NF-κB and MAPK signaling pathways activated by LPS. In conclusion, our studies suggest that myricitrin blocks activation of protects NF-κB and MAPK signaling pathways to nigrostiatum neuron from injury in LPS-stimulated mice and is beneficial to treatment nigrostriatum inflammation of PD.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP17912877	Myricitrin		17912-87-7	Price

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