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Myriocin Induces Apoptotic Lung Cancer Cell Death via Activation of DR4 Pathway

Myriocin Induces Apoptotic Lung Cancer Cell Death via Activation of DR4 Pathway

Kyung Eun Choi, Young Suk Jung, Dea Hwan Kim, Ju Kyung Song, Ji Young Kim, Yu Yeon Jung, So Young Eum, Joo Hwan Kim, Na Young Yoon, Hwan Soo Yoo, Sang-Bae Han, Jin Tae Hong

Arch Pharm Res. 2014 Apr;37(4):501-11.

PMID: 24395529

Abstract:

It has been known that myriocin inhibits melanoma growth. However, the effects and action mechanisms of myriocin on lung cancer cell growth have not been reported. In this study, we examined whether myriocin isolated from Mycelia sterilia inhibits cell growth of lung cancer cells (A549 and NCI-H460) as well as possible signaling pathways involved in cell growth inhibition. Different concentrations of myriocin inhibited the growth of lung cancer cells through the induction of apoptotic cell death. Consistent with cancer cell growth inhibition, myriocin induced the expression of death receptors (DRs) as well as p-JNK and p-p38 in both cell lines. Moreover, the combination of myriocin with DR4 ligand TRAIL, and other well known anti-tumor drugs (docetaxel and cisplatin) synergistically inhibited cancer cell growth, and induced DR4 expression. These results showed that myriocin inhibits lung cancer cells growth through apoptosis via the activation of DR4 pathways, and enhanced anti-cancer effects with well known drugs. Thus, our study indicates that myriocin could be effective for lung cancer cells as an anti-cancer drug and/or a conjunction agent with well known anti-cancers.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP35891704-A	Myriocin from Mycelia sterilia		35891-70-4	Price

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