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N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide Is One of a New Class of Activators for Ca2+-activated, Phospholipid-Dependent Protein Kinase

N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide Is One of a New Class of Activators for Ca2+-activated, Phospholipid-Dependent Protein Kinase

H Nishino, K Kitagawa, A Iwashima, M Ito, T Tanaka, H Hidaka

Biochim Biophys Acta. 1986 Nov 28;889(2):236-9.

PMID: 3778949

Abstract:

N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide (SC-9) activated Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C). SC-9 acted as a substitute for phosphatidylserine, which is one of the endogenous factors in activating protein kinase C. SC-9 was also effective in regulating the physiological functions at the whole-cell level. For example, SC-9 stimulated hexose transport activity in mouse fibroblasts, a protein kinase C-regulated cellular function. Thus, SC-9 may be useful to study the molecular basis of the regulation of protein kinase C activity, and the biological significance of this enzyme.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP102649785	N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide		102649-78-5	Price

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