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N-aryl 2-aryloxyacetamides as a New Class of Fatty Acid Amide Hydrolase (FAAH) Inhibitors

N-aryl 2-aryloxyacetamides as a New Class of Fatty Acid Amide Hydrolase (FAAH) Inhibitors

Naresh Sunduru, Mona Svensson, Mariateresa Cipriano, Sania Marwaha, C David Andersson, Richard Svensson, Christopher J Fowler, Mikael Elofsson

J Enzyme Inhib Med Chem. 2017 Dec;32(1):513-521.

PMID: 28114819

Abstract:

Fatty acid amide hydrolase (FAAH) is a promising target for the development of drugs to treat neurological diseases. In search of new FAAH inhibitors, we identified 2-(4-cyclohexylphenoxy)-N-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide, 4g, with an IC50 of 2.6 µM as a chemical starting point for the development of potent FAAH inhibitors. Preliminary hit-to-lead optimisation resulted in 2-(4-phenylphenoxy)-N-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide, 4i, with an IC50 of 0.35 µM.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP499193543	3-Trimethylsilanylethynyl-pyridine-2-carboxylic acid amide		499193-54-3	Price

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