0

N-Methyl-D-aspartate Acid: A Convulsant With Weak Neurotoxic Properties

R Zaczek, J Collins, J T Coyle

Neurosci Lett. 1981 Jul 2;24(2):181-6.

PMID: 7019775

Abstract:

N-Methyl-D-aspartic acid (NMDA) is 100-fold less potent as a neurotoxin than kainic acid when injected into the rat striatum. However, NMDA, when injected into the hippocampus, causes a more severe seizure disorder than kainic acid and doses of NMDA than produce much smaller lesions than those caused by kainate. These results indicate a poor correlation between convulsant and neurotoxic properties of acidic excitatory amino acids.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP6384925-A N-Methyl-D-aspartic acid N-Methyl-D-aspartic acid 6384-92-5 Price
qrcode