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N-methyl-(R)-3-(tert-butyl)-sulfinyl-1,4-dihydropyridine: A Novel NADH Model Compound

Kun Xie, You-Cheng Liu, Yi Cui, Jian-Ge Wang, Yao Fu, Thomas C W Mak

Molecules. 2007 Mar 12;12(3):415-22.

PMID: 17851400

Abstract:

We have synthesized a novel chiral NADH model compound, N-methyl-(R)-3-(tert-butyl)-sulphinyl-1,4-dihydropyridine with high enantioselectivity and used it in the reduction of methyl benzoylformate, producing (S)-methyl mandelate in 95% ee. The absolute structure of its precursor, 3-(tert-butyl)sulfinyl pyridine, was determined by X-ray analysis.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP15206550 Methyl benzoylformate Methyl benzoylformate 15206-55-0 Price
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