Home
Resources
Publications
N,N-dimethylsphingosine 1-phosphate Activates Human Platelets

N,N-dimethylsphingosine 1-phosphate Activates Human Platelets

Y Yatomi, S Yamamura, F Ruan, S Kume, Y Ozaki, Y Igarashi

FEBS Lett. 1997 Nov 17;417(3):341-4.

PMID: 9409747

Abstract:

We recently reported that N,N-dimethylsphingosine 1-phosphate (DMS-1-P) can be formed from N,N-dimethylsphingosine (DMS) in activated platelets [Y. Yatomi et al., Biochem. Biophys. Res. Commun. 231 (1997) 848-851]. In this study, we synthesized, for the first time, DMS-1-P and examined the functional effects of DMS-1-P and its related sphingolipids on platelets. Although exogenous DMS was inactive, its phosphorylated derivative, DMS-1-P, induced platelet intracellular Ca2+ mobilization and shape change, but not aggregation or release reactions. Since sphingosine 1-phosphate (Sph-1-P) is structurally related to DMS-1-P and activates platelets more strongly than DMS-1-P, a competitive binding experiment for [3H]Sph-1-P was performed using DMS-1-P. DMS-1-P reduced the binding of [3H]Sph-1-P to platelets almost as much as unlabeled Sph-1-P did. These results suggest that DMS-1-P activates platelets via an interaction with a platelet surface receptor for Sph-1-P.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP119567634	N,N-Dimethylsphingosine		119567-63-4	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: