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N,N-dimethylsphingosine Phosphorylation in Human Platelets

N,N-dimethylsphingosine Phosphorylation in Human Platelets

Y Yatomi, Y Ozaki, K Satoh, S Kume, F Ruan, Y Igarashi

Biochem Biophys Res Commun. 1997 Feb 24;231(3):848-51.

PMID: 9070908

Abstract:

Metabolism of sphingosine (Sph) derivatives in human platelets was examined. [3H]Sph was rapidly and heavily phosphorylated into sphingosine 1-phosphate, similarly in resting and stimulated platelets. [14C]N,N-dimethylsphingosine was stable in resting platelets, while it was converted into N,N-dimethylsphingosine 1-phosphate (DMS-1-P), although weakly, in platelets stimulated with thrombin or 12-O-tetradecanoylphorbol 13-acetate. This DMS-1-P formation was inhibited by staurosporine, a potent protein kinase inhibitor. [3H]C2-ceramide was unchanged both in resting and stimulated platelets. Our report is the first to describe production of DMS-1-P in a biological system.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP119567634	N,N-Dimethylsphingosine		119567-63-4	Price

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