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[N-of-1 Trials in Child and Adolescent Psychiatry: A Closer Look at Stimulants]

[N-of-1 Trials in Child and Adolescent Psychiatry: A Closer Look at Stimulants]

E Mordijck, M Danckaerts, P Onghena

Tijdschr Psychiatr. 2018;60(5):315-325.

PMID: 29766479

Abstract:

Background:
An N-of-1 trial is a clinical trial studying the response of an individual to a particular intervention or different interventions in an objective, systematic way.
Aim:
To evaluate both the applications and the methodology of N-of-1 trials in child and adolescent psychiatry.
Method:
A systematic review using PubMed and Embase assessing N-of-1 trials published during the period 1986 - July 2016 with the following key-word: 'N-of-1'.
Results:
20 articles were included. All articles used N-of-1 trials to evaluate the effect of stimulant medications in children and adolescents with ADHD. Most articles recommended the use of the N-of-1 methodology in clinical practice, despite the large variation in methodology and in outcome interpretation of N-of-1 trials. The 20 articles didn't meet the current quality standards for N-of-1 trials.
Conclusion:
Despite the advantages of N-of-1 trials, the applications in child and adolescent psychiatry turn out to be rather limited and specific. N-of-1 trials have more to offer regarding both clinical practice and research in child and adolescent psychiatry. If the methodological recommendations are sufficiently met, N-of-1 trials could provide a useful and applicable tool for the child- and adolescent psychiatrist to offer individual patient care.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP919973834	OF-1		919973-83-4	Price

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