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NAB2-STAT6 Fusion Protein Mediates Cell Proliferation and Oncogenic Progression via EGR-1 Regulation

NAB2-STAT6 Fusion Protein Mediates Cell Proliferation and Oncogenic Progression via EGR-1 Regulation

Ye-Seul Park, Hyeng-Soo Kim, Ju-Heon Kim, Sung-Hun Choi, Da-Som Kim, Zae Young Ryoo, Jae-Young Kim, Sanggyu Lee

Biochem Biophys Res Commun. 2020 May 28;526(2):287-292.

PMID: 32216968

Abstract:

Solitary fibrous tumors are rare mesenchymal tumors derived from soft tissues and vascular walls. NAB2-STAT6 fusion gene serves as a marker gene for this disease and consists of the truncated repressor domain of NGFI-A-Binding protein 2 (NAB2) and the intact activation domain of STAT6. In this study, we found that EGR-1 and the proliferation-related EGR-1 target gene IGF2 were upregulated in NIH-3T3 cells transfected with NAB2-STAT6. Additionally, p-Rb (Ser795) and cyclin D1 levels were upregulated, and cell proliferation was also enhanced. We identified that treatment with the IGF2 inhibitor reduced cell proliferation in NIH-3T3 cells transfected with NAB2-STAT6. The oncogenic progression was enhanced in NIH-3T3 cells transfected with NAB2-STAT6 compared with those transfected with the empty vector. Taken together, our study suggests that the NAB2-STAT6 fusion gene is associated with cell proliferation through EGR-1 transcriptional expression and IGF2 can be a drug target for the treatment of solitary fibrous tumors.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP331859860	Chromeceptin		331859-86-0	Price

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