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NAD as a Genotype-Specific Drug Target

Szu-Chieh Mei, Charles Brenner

Chem Biol. 2013 Nov 21;20(11):1307-8.

PMID: 24267273

Abstract:

Using high-throughput chemical and genetic screening, Matheny and colleagues (in this issue of Chemistry & Biology) identified STF-118804, an inhibitor of nicotinamide phosphoribosyltransferase, as a cell type-specific inhibitor of mixed-lineage leukemia with MLL chromosomal rearrangements. The approach was powerful, as is the potential for NAD as a specific cancer target.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP894187612 STF-118804 STF-118804 894187-61-2 Price
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