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Nanoformulations of Natural Products for Management of Metabolic Syndrome

Yasamin Davatgaran Taghipour, Marziyeh Hajialyani, Rozita Naseri, Mahvash Hesari, Pantea Mohammadi, Azzurra Stefanucci, Adriano Mollica, Mohammad Hosein Farzaei, Mohammad Abdollahi

Int J Nanomedicine. 2019 Jul 16;14:5303-5321.

PMID: 31406461

Abstract:

Metabolic syndrome is a common metabolic disorder which has become a public health challenge worldwide. There has been growing interest in medications including natural products as complementary or alternative choices for common chemical therapeutics regarding their limited side effects and ease of access. Nanosizing these compounds may help to increase their solubility, bioavailability, and promisingly enhance their efficacy. This study, for the first time, provides a comprehensive overview of the application of natural-products-based nanoformulations in the management of metabolic syndrome. Different phytochemicals including curcumin, berberine, Capsicum oleoresin, naringenin, emodin, gymnemic acid, resveratrol, quercetin, scutellarin, stevioside, silybin, baicalin, and others have been nanosized hitherto, and their nanosizing method and effect in treatment and alleviating metabolic syndrome have been reviewed and discussed in this study. It has been discovered that there are several pathways or molecular targets relevant to metabolic disorders which are affected by these compounds. Various natural-based nanoformulations have shown promising effect in treatment of metabolic syndrome, and therefore can be considered as future candidates instead of or in conjunction with pharmaceutical drugs if they pass clinical trials successfully.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP27740018 Scutellarin Scutellarin 27740-01-8 Price
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