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Nanorod Mediated Collagen Scaffolds as Extra Cellular Matrix Mimics

Nanorod Mediated Collagen Scaffolds as Extra Cellular Matrix Mimics

Mohan Vedhanayagam, Ranganathan Mohan, Balachandran Unni Nair, Kalarical Janardhanan Sreeram

Biomed Mater. 2015 Nov 20;10(6):065010.

PMID: 26586667

Abstract:

Creating collagen scaffolds that mimic extracellular matrices without using toxic exogenous materials remains a big challenge. A new strategy to create scaffolds through end-to-end crosslinking through functionalized nanorods leading to well-designed architecture is presented here. Self-assembled scaffolds with a denaturation temperature of 110 °C, porosity of 70%, pore size of 0.32 μm and Young's modulus of 231 MPa were developed largely driven by imine bonding between 3-mercapto-1-propanal (MPA) functionalized ZnO nanorods and collagen. The mechanical properties obtained were much higher than that of native collagen, collagen-MPA, collagen-3-mercapto-1-propanol (3MPOH) or collagen- 3-MPOH-ZnO, clearly bringing out the relevance of nanorod mediated assembly of fibrous networks. This new strategy has led to scaffolds with mechanical properties much higher than earlier reports and can provide support for cell growth and facilitation of cell attachment.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP19721223	3-Mercapto-1-propanol		19721-22-3	Price

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