Home
Resources
Publications
Narirutin Fraction From Citrus Peels Attenuates LPS-stimulated Inflammatory Response Through Inhibition of NF-κB and MAPKs Activation

Narirutin Fraction From Citrus Peels Attenuates LPS-stimulated Inflammatory Response Through Inhibition of NF-κB and MAPKs Activation

Sang Keun Ha, Ho-Young Park, Hyojin Eom, Yoonsook Kim, Inwook Choi

Food Chem Toxicol. 2012 Oct;50(10):3498-504.

PMID: 22813871

Abstract:

In this study, we examined the regulatory activity of narirutin fraction from citrus peels on the production of inflammatory mediators managing acute or chronic inflammatory diseases in macrophages. Narirutin fraction inhibited the release, by lipopolysaccharide (LPS)-stimulated macrophages, of nitric oxide (NO) and prostaglandin E2 (PGE2) through suppressing the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), respectively. The release, by LPS stimulated macrophages, of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) was also reduced by narirutin fraction in a dose-dependent manner. Furthermore, narirutin fraction inhibited the LPS-mediated activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinases (MAPKs), which are signaling molecules involved in production of pro-inflammatory factors. As a result of these properties, narirutin fraction has the potential to be used as a functional dietary supplement and effective anti-inflammatory agent.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP14259462	Narirutin		14259-46-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: