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Natural Xanthones From Garcinia Mangostana With Multifunctional Activities for the Therapy of Alzheimer's Disease

Natural Xanthones From Garcinia Mangostana With Multifunctional Activities for the Therapy of Alzheimer's Disease

Sheng-Nan Wang, Qian Li, Ming-Hua Jing, Espargaró Alba, Xiao-Hong Yang, Raimon Sabaté, Yi-Fan Han, Rong-Biao Pi, Wen-Jian Lan, Xiao-Bo Yang, Jing-Kao Chen

Neurochem Res. 2016 Jul;41(7):1806-17.

PMID: 27038926

Abstract:

Natural xanthones have diversity pharmacological activities. Here, a series of xanthones isolated from the pericarps of Garcinia mangostana Linn, named α-Mangostin, 8-Deoxygartanin, Gartanin, Garciniafuran, Garcinone C, Garcinone D, and γ-Mangostin were investigated. Biological screening performed in vitro and in Escherichia coli cells indicated that most of the xanthones exhibited significant inhibition of self-induced β-amyloid (Aβ) aggregation and also β-site amyloid precursor protein-cleaving enzyme 1, acted as potential antioxidants and biometal chelators. Among these compounds, α-Mangostin, Gartanin, Garcinone C and γ-Mangostin showed better antioxidant properties to scavenge Diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH) free radical than Trolox, and potent neuroprotective effects against glutamate-induced HT22 cell death partly by up-regulating HO-1 protein level and then scavenging reactive oxygen species. Moreover, Gartanin, Garcinone C and γ-Mangostin could be able to penetrate the blood-brain barrier (BBB) in vitro. These findings suggest that the natural xanthones have multifunctional activities against Alzheimer's disease (AD) and could be promising compounds for the therapy of AD.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP107390089	Garcinone D		107390-08-9	Price

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