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NE-100, a Novel Sigma Receptor Ligand: Effect on Phencyclidine-Induced Behaviors in Rats, Dogs and Monkeys

NE-100, a Novel Sigma Receptor Ligand: Effect on Phencyclidine-Induced Behaviors in Rats, Dogs and Monkeys

S Okuyama, Y Imagawa, T Sakagawa, A Nakazato, K Yamaguchi, M Katoh, S Yamada, H Araki, S Otomo

Life Sci. 1994;55(7):PL133-8.

PMID: 8041225

Abstract:

Phencyclidine (PCP)-induced psychosis is a useful animal model for studies on schizophrenia. N, N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)-phenyl]- ethylamine monohydrochloride (NE-100) had no effect on conditioned avoidance responses (CAR) in rats, whereas, the PCP-induced impairment of avoidance inhibition was attenuated by NE-100. The PCP-induced ataxia or decreased attention in rhesus monkeys was to some extent overcome by NE-100. In dogs, PCP-induced either head-weaving behavior or ataxia, effects which were blocked by NE-100. Administration of PCP led to an increase in beta-2 and a decrease in delta relative power (RP) activity in cortical background spectral electroencephalographics (ECoG) in dogs. While NE-100 in itself showed no significant change in beta-2 and delta RP, NE-100 did block the PCP-induced beta-2 increase and delta decrease. These findings indicate that NE-100 attenuates the effect of PCP in experimental animals. This drug is being considered as a therapeutic for the treatment of patients in the schizophrenia.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP149409574	NE-100		149409-57-4	Price

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