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Nematicidal Coumarins From Heracleum Candicans Wall

Nematicidal Coumarins From Heracleum Candicans Wall

Xing-Biao Wang, Guo-Hong Li, Lei Li, Li-Jun Zheng, Rong Huang, Ke-Qin Zhang

Nat Prod Res. 2008 May 20;22(8):666-71.

PMID: 18569707

Abstract:

The root extract of Heracleum candicans Wall. exhibited antagonistic activities against nematodes Bursaphelenchus xylophilus (Steiner et Buhrer) Nickle and Panagrellus redivivus (Linn.) Goodey. Through bioassay-guided fractionations, three coumarins were obtained from the extract of H. candicans and determined to be 8-geranyloxypsoralen (1), imperatorin (2), and heraclenin (3) based on spectra data. All three compounds possessed nematicidal activities against the two tested nematodes. The median lethal concentrations (LC(50)) of compounds 1-3 at 72 h were 188.3, 161.7, and 114.7 mg L(-1) respectively against B. xylophilus and were 117.5, 179.0, and 148.7 mg L(-1) respectively against P. redivivus. This is the first report about species in the Umbelliferae family that possesses nematicidal activity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP7437550	8-Geranyloxypsoralen		7437-55-0	Price

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