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Neural-derived Estradiol Regulates Brain Plasticity

Iñigo Azcoitia, Maria Angeles Arevalo, Luis M Garcia-Segura

J Chem Neuroanat. 2018 Apr;89:53-59.

PMID: 28414121

Abstract:

In addition to be an ovarian hormone, estradiol is a neurosteroid synthesized by neural cells. The brain is a steroidogenic tissue that metabolizes testosterone to estradiol. The last step in the synthesis of estradiol is catalyzed by the enzyme aromatase, which is widely expressed in the brain of male and female animals and humans. Studies that have manipulated the expression or the activity of aromatase have revealed that brain-derived estradiol acts as a neuromodulator and regulates different forms of brain plasticity in male and female animals. The regulation of neuroplastic events by brain-derived estradiol probably participates in the effects of brain aromatase on behavior and cognition.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP50282-B Estradiol Estradiol 50-28-2 Price
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