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Neuraminic Acid Derivatives Newly Discovered in Humans: N-acetyl-9-O-L-lactoylneuraminic Acid, N,9-O-Diacetylneuraminic Acid and N-acetyl-2,3-dehydro-2-deoxyneuraminic Acid

Neuraminic Acid Derivatives Newly Discovered in Humans: N-acetyl-9-O-L-lactoylneuraminic Acid, N,9-O-Diacetylneuraminic Acid and N-acetyl-2,3-dehydro-2-deoxyneuraminic Acid

J Haverkamp, R Schauer, M Wember

Hoppe Seylers Z Physiol Chem. 1976 Dec;357(12):1699-705.

PMID: 1017796

Abstract:

The free and glycosidically bound acylneuraminic acids from human serum and saliva and the free acylneuraminic acids from human urine have been characterized by thin-layer chromatography and gas-liquid chromatography/mass spectrometry. Acylneuraminic acid mixtures obtained from serum and saliva contain mainly N-acetylneuraminic acid and N-acetyl-9-O-L-lactoylneuraminic acid, whereas small amounts of N,9-O-diacetylneuraminic acid are also present. No free N,O-diacylneuraminic acids could be detected in the urine samples. None of the investigated fluids contained N-glycoloylneuraminic acid. The unsaturated N-acetyl-2,3-dehydro-2-deoxyneuraminic acid is usually a component of the free acylneuraminic acid fractions of serum, saliva and urine. The body fluids of a patient with sialuria contain the same O-acylated and unsaturated N-acetyl neuraminic acid derivatives as mentioned above, but the total amounts of free acylneuraminic acids in these materials are significantly higher than found for normal persons.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP24967279	N-Acetyl-2,3-dehydro-2-deoxyneuraminic acid		24967-27-9	Price

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