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Neurite Outgrowth Enhancement by Jiadifenolide: Possible Targets

R A Shenvi

Nat Prod Rep. 2016 Apr;33(4):535-9.

PMID: 26891462

Abstract:

Covering: 1860-2016A mechanistic link may exist between convulsant plant substances typified by picrotoxinin, and 'neurotrophic' sesquiterpenes like jiadifenolide. Picrotoxinin elicits convulsion by anion blockade of the Cys-loop family of neurotransmitter-gated ion channels. These same receptors mediate neuronal development and neurite outgrowth prior to synapse formation. Due to its structural homology with picrotoxin and anisatin, it is possible that jiadifenolide enhances NGF-stimulated neurite outgrowth by modulation of the Cys-loop family of receptors.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP5230875 Anisatin Anisatin 5230-87-5 Price
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