Home
Resources
Publications
Neuromedin B-32 and B-30: Two "Big" Neuromedin B Identified in Porcine Brain and Spinal Cord

Neuromedin B-32 and B-30: Two "Big" Neuromedin B Identified in Porcine Brain and Spinal Cord

N Minamino, T Sudoh, K Kangawa, H Matsuo

Biochem Biophys Res Commun. 1985 Jul 31;130(2):685-91.

PMID: 4026853

Abstract:

In mammalian spinal cord, we have previously discovered "neuromedin B", whose structure is closely related to amphibian bombesin. By utilizing a specific radioimmunoassay for neuromedin B, we have isolated two novel "big" neuromedin B, designated neuromedin B-32 and B-30, from pig brain and spinal cord, both of which were identified as N-terminally extended forms of neuromedin B. The amino acid sequence of neuromedin B-32 was determined to be: Ala-Pro-Leu-Ser-Trp-Asp-Leu-Pro-Glu-Pro- Arg-Ser-Arg-Ala-Gly-Lys-Ile-Arg-Val-His-Pro-Arg-Gly-Asn-Leu-Trp-Ala- Thr-Gly-His-Phe-Met-NH2, while neuromedin B-30 was found to be an N-terminal two amino acids deleted form of neuromedin B-32. Isolation of a family comprising neuromedin B, B-30 and B-32 is indicative of their biosynthetic relationship.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP87096842	Neuromedin B		87096-84-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: