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Neuropharmacological Effects of Aconiti Lateralis Radix Praeparata

Neuropharmacological Effects of Aconiti Lateralis Radix Praeparata

Lihong Zhao, Zhihui Sun, Limin Yang, Ranji Cui, Wei Yang, Bingjin Li

Clin Exp Pharmacol Physiol. 2020 Apr;47(4):531-542.

PMID: 31837236

Abstract:

Aconiti Lateralis Radix Praeparata (Fuzi in Chinese), which are the lateral roots of Aconitum Carmichaelii Debx, is widely used in China to treat many neurological diseases. Fuzi, in its various forms, has many neuropharmacological effects. It can act as an analgesic and help with depression, epilepsy, and dementia. However, the neuropharmacological effects of Aconiti Lateralis Radix Praeparata are seldom comprehensively reviewed. In this review, the neuropharmacological activities of some components contained in Aconiti Lateralis Radix Praeparata are considered. These include aconitine, mesaconitine, hypaconitine, total alkaloid, polysaccharide-1, benzoylmesaconine, fuziline, songorine, and napelline. We also specifically discuss the antidepressant effects of total alkaloids and polysaccharide-1. This review may provide a theoretical basis for further utilization of Aconiti Lateralis Radix Praeparata for diseases that affect the central nervous system.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP80665721	Fuziline		80665-72-1	Price

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