Home
Resources
Publications
Neuropoietin, a New IL-6-related Cytokine Signaling Through the Ciliary Neurotrophic Factor Receptor

Neuropoietin, a New IL-6-related Cytokine Signaling Through the Ciliary Neurotrophic Factor Receptor

Damien Derouet, François Rousseau, Fabienne Alfonsi, Josy Froger, Jacques Hermann, Fabien Barbier, David Perret, Caroline Diveu, Catherine Guillet, Laurence Preisser, Agnès Dumont, Maud Barbado, Alain Morel, etc.

Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4827-32.

PMID: 15051883

Abstract:

A structural profile-based computational screen was used to identify neuropoietin (NP), a new cytokine. The np gene is localized in tandem with the cardiotrophin-1 gene on mouse chromosome 7. NP shares structural and functional features with ciliary neurotrophic factor (CNTF), cardiotrophin-1, and cardiotrophin-like cytokine. It acts through a membrane receptor complex comprising CNTF receptor-alpha component (CNTFRalpha), gp130, and leukemia inhibitory factor receptor to activate signal transducer and activator of transcription 3 signaling pathway. NP is highly expressed in embryonic neuroepithelia. Strikingly, CNTFRalpha, but not its alternate ligands, CNTF and cardiotrophin-like cytokine, is expressed at the same developmental stages. NP is also observed in retina and to a lesser extent in skeletal muscle. Moreover, NP could sustain the in vitro survival of embryonic motor neurons and could increase the proliferation of neural precursors when associated to epidermal growth factor and fibroblast growth factor 2. Thus, NP is a new ligand for CNTFRalpha, with important implications for murine nervous system development.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413416	Neuropoietin from mouse			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: