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Neuroprotective Effects of 3,5-dicaffeoylquinic Acid on Hydrogen Peroxide-Induced Cell Death in SH-SY5Y Cells

Neuroprotective Effects of 3,5-dicaffeoylquinic Acid on Hydrogen Peroxide-Induced Cell Death in SH-SY5Y Cells

Sung-Soo Kim, Ran-Young Park, Hyun-Jung Jeon, Yong-Soo Kwon, Wanjoo Chun

Phytother Res. 2005 Mar;19(3):243-5.

PMID: 15934031

Abstract:

Oxidative stress plays an important role in the pathological processes of a variety of neurodegenerative diseases. The neuroprotective effects of 3,5-diCQA and 3,4-diCQA, two caffeoylquinic acid derivatives present in Dipsacus asper, on hydrogen peroxide (H2O2)-induced neuronal cell damage were evaluated in this study.SH-SY5Y cells treated with H2O2 exhibited a decrease in survival and intracellular glutathione and also an increase in the caspase-3 activity. However, pretreatment of cells with 3,5-diCQA attenuated the neuronal death and caspase-3 activation induced by H2O2. In addition, 3,5-diCQA restored H2O2-induced depletion of intracellular glutathione. 3,5-diCQA showed significant protective effects although it could not completely suppress H2O2-induced cell injury to control levels. The data suggest that 3,5-diCQA might be a potential therapeutic agent for treating or preventing neurodegenerative diseases implicated with oxidative stress.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2450535	3,5-Dicaffeoylquinic acid		2450-53-5	Price

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