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Neuropsychiatric Involvement in Lupus Is Associated With the Nogo-a/NgR1 Pathway

Neuropsychiatric Involvement in Lupus Is Associated With the Nogo-a/NgR1 Pathway

Hong-Wei Lei, Jing-Yuan Wang, Qiu-Jie Dang, Fan Yang, Xin Liu, Ji-Hui Zhang, Yang Li

J Neuroimmunol. 2017 Oct 15;311:22-28.

PMID: 28807492

Abstract:

Neuroinflammation- and neurodegeneration-induced nerve injury may represent important components of neuropsychiatric lupus (NPSLE). Myelin-associated neurite outgrowth inhibitor (Nogo)-a and its receptor, NgR1, limit recovery of the adult central nervous system after injury. We detected a soluble Nogo-a product in the cerebral spinal fluid of patients with NPSLE. In a mouse model of lupus, aging was associated with an increase in Nogo-a positive neurons, diminished myelin sheaths, enhanced pro-inflammatory cytokines, and impaired cognition and memory. Treatment with the Nogo-66 antagonist promoted myelin repair, improved cognition and memory, and downregulated pro-inflammatory factors. Our data imply the Nogo-a/NgR1 pathway is involved in NPSLE.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42414850	Nogo-66(1-40) antagonist peptide			Price

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