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[Neutralizing Capacity, Pepsin Inactivation and Binding to Bile Acids and Lysolecithin of the Antacid Magaldrate (Author's Transl)]

[Neutralizing Capacity, Pepsin Inactivation and Binding to Bile Acids and Lysolecithin of the Antacid Magaldrate (Author's Transl)]

C Baur, A Becker, R Linder, T Schwan

Arzneimittelforschung. 1981;31(3):504-7.

PMID: 6784737

Abstract:

The neutralizing capacity of pentaaluminum-decamagnesiumhentriacontahydroxide-bis(sulfate)-hydrate (magaldrate, Riopan), a stable Al-Mg-hydroxide mono-substance, determined by a modification of the method described in literature, surpasses the efficacy index (mval divided by g) of various commercial antacids. These results coincide with the findings of other workers. The intragastric pH is rapidly and consistently raised to a value between 3 and 5 which is not exceeded (no acid rebound). Due to this fact, pepsin is inactivated and finally adsorbed by magaldrate. Moreover, magaldrate binds a considerable amount of substances contained in duodeno-gastric reflux, such as bile acids and lysolecithin (aggressors in case of gastritis, peptic ulcer, stress ulcer, peptic esophagitis).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP17927650	Aluminum sulfate hydrate		17927-65-0	Price

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