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New 3'-O-aromatic acyl-5-fluoro-2'-deoxyuridine Derivatives as Potential Anticancer Agents

Agnieszka Szymańska-Michalak, Dariusz Wawrzyniak, Grzegorz Framski, Marta Kujda, Paulina Zgoła, Jacek Stawinski, Jan Barciszewski, Jerzy Boryski, Adam Kraszewski

Eur J Med Chem. 2016 Jun 10;115:41-52.

PMID: 26994842

Abstract:

New aromatic and aliphatic 3'-O-acyl-5-fluoro-2'-deoxyuridine derivatives were synthesized and evaluated as candidates for prodrugs against various cancer cell lines. As the most promising candidate for antimalignant therapeutics was found a dual-acting acyl derivative 7h, which apparently released not only the known anticancer nucleoside, 5-fluoro-2'-deoxyuridine (FdU), but also an additional active metabolite, acetylsalicylic acid, reinforcing thus therapeutic effect of FdU. Promising therapeutic indices showed also some aromatic dicarboxylic acids derivatives decorated with FdU esters (11 and 12).

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1015071223 5-Fluoro-2,3-thiophenedicarboxaldehyde 5-Fluoro-2,3-thiophenedicarboxaldehyde 1015071-22-3 Price
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