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New 9, 19-cycloartane Triterpenoid From the Root of Cimicifuga Foetida

Di-Fan Zhu, Yin Nian, Hai-Yan Wang, Zhi-Run Zhang, Yan-Bo Song, Rong-Tao Li, Ming-Hua Qiu

Chin J Nat Med. 2014 Apr;12(4):294-6.

PMID: 24863355

Abstract:

Aim:
To study the 9, 19-cycloartane triterpenes from the roots of Cimicifuga foetida.
Method:
Chromatographic separations by silica gel, C18 reversed phase silica gel, and high-performance liquid chromatography (HPLC) were used. All of the structures were elucidated on the basis of spectroscopic analysis and chemical methods.
Results:
Five 9, 19-cycloartane triterpenes, (3β, 12β, 15α, 24R)-12, 2'-diacetoxy-24, 25-epoxy-15-hydroxy-16, 23-dione-3-O-α-L-arabinopyranoside (1), actein (2), 23-epi-26-deoxyactein (3), asiaticoside B (4), and 12β-hydroxycimigenol (5) were isolated from the roots of Cimicifuga foetida.
Conclusion:
Compound 1 is a new triterpene with two acetoxy groups at C-2' and C-12.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
LPLC81602 C18-Reversed phase silica gel C18-Reversed phase silica gel Price
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