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New Bioluminescent Coelenterazine Derivatives With Various C-6 Substitutions

Tianyu Jiang, Xingye Yang, Yubin Zhou, Ilia Yampolsky, Lupei Du, Minyong Li

Org Biomol Chem. 2017 Aug 23;15(33):7008-7018.

PMID: 28795755

Abstract:

A series of new coelenterazine analogs with varying substituents at the C-6 position of the imidazopyrazinone core have been designed and synthesized for the extension of bioluminescence substrates. Some of them display excellent bioluminescence properties compared to DeepBlueC™ or native coelenterazine with both in vitro and in vivo biological evaluations, thus placing these derivatives among the most ideal substrates for Renilla bioluminescence applications.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP55779481 Coelenterazine, native Coelenterazine, native 55779-48-1 Price
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