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New Coumarin From the Roots of Prangos Pabularia

New Coumarin From the Roots of Prangos Pabularia

Sodik Numonov, Khayrulla Bobakulov, Mukhabbat Numonova, Farukh Sharopov, William N Setzer, Qosimjon Khalilov, Nurmirza Begmatov, Maidina Habasi, Haji Akber Aisa

Nat Prod Res. 2018 Oct;32(19):2325-2332.

PMID: 29224384

Abstract:

The new coumarin 1, yuganin A (7-methoxy-8-((1S,2S)-1,2,3-trihydroxy-3-methylbutyl)-2H-chromen-2-one) along with nine known coumarins, heraclenol 3'-O-β-D-glucopyranoside (2), oxypeucedanin hydrate 3'-O-β-D-glucopyranoside (3), heraclenol (4), oxypeucedanin hydrate (5), osthole (6), oxypeucedanin (7), heraclenin (8), isoimperatorin (9), imperatorin (10) and the disaccharide sucrose (11), have been isolated from the roots of Prangos pabularia, and the structures of these isolated compounds were elucidated by spectroscopic means, especially, UV, HR-ESIMS, and 1D and 2D NMR spectroscopy. Furthermore, the anti-melanogenic effect of yuganin A and its inhibitory effect on B16 cells were evaluated. Yuganin A may be useful in the treatment of hyperpigmentation and as a skin-whitening agent in the cosmetics industry.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP35740182	(±)-Heraclenin		35740-18-2	Price

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