Home
Resources
Publications
New Developments in Optimizing Bronchodilator Treatment of COPD: A Focus on glycopyrrolate/formoterol Combination Formulated by Co-Suspension Delivery Technology

New Developments in Optimizing Bronchodilator Treatment of COPD: A Focus on glycopyrrolate/formoterol Combination Formulated by Co-Suspension Delivery Technology

Anthony D D'Urzo, Mario Cazzola, Nicola A Hanania, Roland Buhl, M Reza Maleki-Yazdi

Int J Chron Obstruct Pulmon Dis. 2018 Sep 7;13:2805-2819.

PMID: 30233171

Abstract:

COPD causes considerable health and economic burden worldwide, with incidence of the disease expected to continue to rise. Inhaled bronchodilators, such as long-acting muscarinic antagonists (LAMAs) and long-acting β2-agonists (LABAs), are central to the maintenance treatment of patients with COPD. Clinical studies have demonstrated that combined LAMA + LABA therapies improve efficacy while retaining a safety profile similar to LAMA or LABA alone. This has led to the development of several LAMA/LABA fixed-dose combination (FDC) therapies, which provide patients with the convenience of two active compounds in a single inhaler. GFF MDI (Bevespi Aerosphere®) is an FDC of glycopyrrolate/formoterol fumarate 18/9.6 µg formulated using innovative co-suspension delivery technology for administration via metered dose inhaler (MDI). GFF MDI was developed to make a treatment option available for patients who have a requirement or preference to use an MDI, rather than a dry powder or soft mist inhaler. Now that several LAMA/LABA FDCs have been approved for use in COPD, we review the impact of dual-bronchodilator treatment on COPD therapy and discuss recent clinical studies that are helping to develop a more comprehensive understanding of how LAMA/LABA FDCs can improve patient outcomes.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP618882	Glycopyrrolate Related Compound A		618-88-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: