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New Flavonol and Diterpenoids From the Endophytic Fungus Aspergillus Sp. YXf3

Tong Yan, Zhi Kai Guo, Rong Jiang, Wei Wei, Ting Wang, Ye Guo, Yong Chun Song, Rui Hua Jiao, Ren Xiang Tan, Hui Ming Ge

Planta Med. 2013 Mar;79(5):348-52.

PMID: 23457022

Abstract:

One new flavonol, chlorflavonin A (1), four new diterpenoids, aspergiloids E-H (3, 5-7), together with eight known compounds (2, 4, 8-13) were isolated from solid fermentation of Aspergillus sp. (strain no. YXf3), an endophytic fungus from Ginkgo biloba. Their structures were determined through detailed spectroscopic analysis combined with comparison of NMR spectra data with reported ones. All of them were screened on cytotoxicity against KB, SGC-7901, SW1116, and A549 cell lines; compounds 4, 9-11 exhibited moderate activities with IC50 values ranging from 6.74 to 46.64 µM.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP23363646 Chlorflavonin Chlorflavonin 23363-64-6 Price
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