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New Geldanamycin Analogs From Streptomyces Hygroscopicus

New Geldanamycin Analogs From Streptomyces Hygroscopicus

Cheng-Zhu Wu, Jae-Hyuk Jang, Jong Seog Ahn, Young-Soo Hong

J Microbiol Biotechnol. 2012 Nov;22(11):1478-81.

PMID: 23124337

Abstract:

Geldanamycin (GM) and its analogs are important anticancer agents that inhibit heat shock protein (Hsp) 90, which is a major chaperone protein in cancer cells. Accordingly, based on interest in obtaining novel natural GM derivatives, the potential of Streptomyces hygroscopicus JCM4427, a GM producer, was explored for novel natural GM derivative(s), resulting in the discovery of new GM analogs as a biosynthetic shunt product and intermediates from its fermentation broth. In this study, the fermentation, isolation, structure determination, and biological activity of the compounds, two new tetracyclic thiazinogeldanamycin (1) and 19-hydroxy-4,5-dihydrogeldanamycin (3), together with the three known 4,5-dihydrothiazinogeldanamycin (2), reblastatin (4), and 17-demethoxy-reblastatin (5), are described.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP30562346-A	Geldanamycin from Streptomyces hygroscopicus		30562-34-6	Price

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