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New La(III) Complex Immobilized on 3-aminopropyl-functionalized Silica as an Efficient and Reusable Catalyst for Hydrolysis of Phosphate Ester Bonds

New La(III) Complex Immobilized on 3-aminopropyl-functionalized Silica as an Efficient and Reusable Catalyst for Hydrolysis of Phosphate Ester Bonds

Alfredo A Muxel, Ademir Neves, Maryene A Camargo, Adailton J Bortoluzzi, Bruno Szpoganicz, Eduardo E Castellano, Nathalia Castilho, Tiago Bortolotto, Hernán Terenzi

Inorg Chem. 2014 Mar 17;53(6):2943-52.

PMID: 24588718

Abstract:

Described herein is the synthesis, structure, and monoesterase and diesterase activities of a new mononuclear [La(III)(L(1))(NO3)2] (1) complex (H2L(1) = 2-bis[{(2-pyridylmethyl)-aminomethyl}-6-[N-(2-pyridylmethyl) aminomethyl)])-4-methyl-6-formylphenol) in the hydrolysis of 2,4-bis(dinitrophenyl)phosphate (2,4-BDNPP). When covalently linked to 3-aminopropyl-functionalized silica, 1 undergoes disproportionation to form a dinuclear species (APS-1), whose catalytic efficiency is increased when compared to the homogeneous reaction due to second coordination sphere effects which increase the substrate to complex association constant. The anchored catalyst APS-1 can be recovered and reused for subsequent hydrolysis reactions (five times) with only a slight loss in activity. In the presence of DNA, we suggest that 1 is also converted into the dinuclear active species as observed with APS-1, and both were shown to be efficient in DNA cleavage.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS761201	3-Aminopropyl functionalized silica			Price

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