0

New Ligands for Human C-reactive Protein: Calcium-Dependent Binding With Epsilon-Aminocaproic Acid-Agarose and Calcium-Independent Binding With Omega-Aminohexyl-Agarose

S Kuwajima, T Kishida, T Noda, Y Izumi, K Naka, T Matsui, K Okuda

Int J Tissue React. 1990;12(2):71-6.

PMID: 2210970

Abstract:

Human C-reactive protein (CRP) is an acute phase protein which increases in concentration in response to inflammation. CRP has been known to bind with phosphorylcholine in a calcium-dependent manner. In this study, CRP is found to bind to affinity chromatography of negatively-charged epsilon-aminocaproic acid-agarose when calcium ions are present, and to the affinity chromatography of positively-charged omega-aminohexyl-agarose if a normal ionic strength of NaCl exists but calcium ion is not present.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP58856738 ω-Aminohexyl-Agarose ω-Aminohexyl-Agarose 58856-73-8 Price
qrcode