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New Mono-Ether of Glycerol and Triterpenes With DPPH Radical Scavenging Activity From Cameroonian Propolis

New Mono-Ether of Glycerol and Triterpenes With DPPH Radical Scavenging Activity From Cameroonian Propolis

Emmanuel Talla, Alfred Ngenge Tamfu, Isaac Sylvère Gade, Lambert Yanda, Joseph Tanyi Mbafor, Sophie Laurent, Luce Vander Elst, Milena Popova, Vassya Bankova

Nat Prod Res. 2017 Jun;31(12):1379-1389.

PMID: 27841022

Abstract:

The extracts of some propolis samples were analysed by GC-MS and then purified by column chromatography. The latter led to the isolation of a new mono-ether of glycerol, 1'-O-eicosanyl glycerol and a new triterpene, methyl-3β,27-dihydroxycycloart-24-en-26-oate together with known triterpenoids namely betulin, 3β-hydroxylanostan-9,24-dien-21-oic acid, mangiferonic acid, a mixture of ambolic acid and β-sitosterol, 3β-hydroxycycloartan-12,24(25)-diene and 27-hydroxymangiferonic acid. The DPPH radical scavenging potential of some extracts and compounds were measured. The radical scavenging activity varied from Hexane extract of Foumban propolis (IC50 = 5.6 mg/mL) to Methanol extract of Foumban propolis (IC50 = 1.07 mg/mL) for the extracts and from 3β-hydroxylanostan-9,24-dien-21-oic acid (IC50 = 1.22 mg/mL) to 1'-O-eicosanyl glycerol (IC50 = 0.93 mg/mL) for the compounds. Activities of samples were moderate as they remained closer to those of the standard antioxidants Gallic acid (IC50 = 0.30 mg/mL) and vitamin C (IC50 = 0.80 mg/mL), especially 1'-O-eicosanyl glycerol, the most active compound.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AS23122	Glycerol standard for IC			Price

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