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New β N-octadecanoyl-5-hydroxytryptamide: antinociceptive effect and possible mechanism of action in mice

New β N-octadecanoyl-5-hydroxytryptamide: antinociceptive effect and possible mechanism of action in mice

Thais Biondino Sardella Giorno, Iris Gonçalvez da Silva Moreira, Claudia Moraes Rezende, Patricia Dias Fernandes

Sci Rep. 2018 Jul 3;8(1):10027.

PMID: 29968799

Abstract:

The present study examined the potential antinociceptive activity of C18 5-HT (βN-octadecanoyl-5-hydroxytryptamide) using chemical and thermal nociception models in mice. Orally administered C18 5-HT (0.1, 1 and 10 mg/kg) produced significant dose-dependent antinociceptive effects in formalin-, capsaicin- and glutamate-induced licking models. This compound also induced a significant increase in the response to thermal stimuli in the hot plate test, and its antinociceptive effect was not related to muscle relaxant or sedative actions. In a thermal hyperalgesia model, C18 5-HT presented an anti-hyperalgesic profile as evidenced by the increase in the response time of the animals. Furthermore, intraperitoneal (i.p) pretreatment with naloxone (a non-selective opioid receptor antagonist, 1 mg/kg), ondansetron (serotoninergic receptor antagonist (5-HT3 subtype), 0.5 mg/kg) or AM241 (CB1 cannabinoid receptor antagonist, 1 mg/kg) reversed the antinociceptive effects of C18 5-HT in the hot plate model. In the formalin-induced licking model, pretreatment with naloxone reversed the antinociceptive effects of C18 5-HT, as demonstrated by an increase in the paw licking response when compared with the C18 5-HT-treated group. These findings suggest that C18 5-HT has peripheral and central antinociceptive effects and that its mechanism of action involves, ate least in part, opioid, serotoninergic and cannabinoid pathways.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP119812292	Ondansetron Related Compound A		119812-29-2	Price

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