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New Phenylpropanoid and 6H-dibenzo[b,d]pyran-6-one Derivatives From the Stems of Dasymaschalon Rostratum

Zhang-Xin Yu, Zhi-Gang Niu, Xiao-Bao Li, Cai-Juan Zheng, Xin-Ming Song, Guang-Ying Chen, Xiao-Ping Song, Chang-Ri Han, Shu-Xian Wu

Fitoterapia. 2017 Apr;118:27-31.

PMID: 28229940

Abstract:

Three new phenylpropanoid derivatives, dasymaroacid A (1), dasymaroesters B and C (2 and 3), and one new polyoxygenated 6H-dibenzo[b,d]pyran-6-one derivative dasymarolactone D (4), together with seven known compounds (5-11), were isolated from the stems of Dasymaschalon rostratum Merr. Compounds 1 and 2 are unusual phenylpropanoid derivatives with a polymethyl substituted cyclopentene conjugated diketone as a substituent, and 3 is a unique cinnamic acid detective with a polymethyl substituted cyclohexene conjugated triketone as a substituent. Their structures were elucidated by extensive spectroscopic methods and chemical method, and 4 was further confirmed by the single crystal X-ray diffraction method. Compounds 1-4 and 7 showed weak anti-HIV-1 activities with EC50 values ranged from 16.44 to 25.91μM.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP668983979 Dibenzo[b,d]thien-2-ylboronic acid Dibenzo[b,d]thien-2-ylboronic acid 668983-97-9 Price
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