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New Phenylpropanoids From Bulbophyllum Retusiusculum

New Phenylpropanoids From Bulbophyllum Retusiusculum

Yun-Shan Fang, Ming-Hui Yang, Le Cai, Jia-Peng Wang, Tian-Peng Yin, Jing Yu, Zhong-Tao Ding

Arch Pharm Res. 2018 Nov;41(11):1074-1081.

PMID: 30151611

Abstract:

Two new phenylpropanoids, retusiusines A (1) and B (2), and a pair of new phenylpropyl enantiomers, (±)-retusiusine C (3a and 3b), together with eight known compounds, dihydroconiferyl dihydro-p-coumarate (4), methyl 3-(4-hydroxyphenyl) propionate (5), 3-(4-hydroxyphenyl)-propanoic acid (6), dihydroferulic acid (7), methyl 3-(4-methoxyphenyl) propionate (8), 3-(3,4-dimethoxyphenyl)-2-propenal (9), trans-p-coumaric acid (10) and dihydroconiferyl alcohol (11), were isolated from the tubers of Bulbophyllum retusiusculum. The absolute configurations of the new compounds were determined by calculating their electronic circular dichroism (ECD), spectra and specific optical rotations and comparing the calculated values with the experimental data. Compound 2 exhibited potent antifungal activity against Candida albicans (16 μg/mL). Compound 3 showed moderate antibacterial activity against Bacillus subtilis (64 μg/mL).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP501984-A	trans-p-Coumaric acid		501-98-4	Price

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