0

New Prostaglandin Derivative for Glaucoma Treatment

Elena Perrino, Caterina Uliva, Cecilia Lanzi, Piero Del Soldato, Emanuela Masini, Anna Sparatore

Bioorg Med Chem Lett. 2009 Mar 15;19(6):1639-42.

PMID: 19233645

Abstract:

A hydrogen sulphide-releasing derivative of latanoprost acid (ACS 67) was synthesized and tested in vivo to evaluate its activity on reduction of intraocular pressure and tolerability. Glutathione (GSH) and cGMP content were also measured in the aqueous humour. The increased reduction of intraocular pressure, with a marked increase of GSH and cGMP and the related potential neuroprotective properties, make this compound interesting for the treatment of glaucoma. This is the first time that an application of a hydrogen sulphide-releasing molecule is reported for the treatment of ocular diseases.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP41639832-A Latanoprost Related Compound E Latanoprost Related Compound E 41639-83-2 Price
AP913258341 Latanoprost Related Compound A Latanoprost Related Compound A 913258-34-1 Price
qrcode