Home
Resources
Publications
New Stationary Phase Based on Beta-Cyclodextrin for Normal-Phase HPLC Group-Separation of Organic Nitrates

New Stationary Phase Based on Beta-Cyclodextrin for Normal-Phase HPLC Group-Separation of Organic Nitrates

M Wössner, K Ballschmiter

Fresenius J Anal Chem. 2000 Feb;366(4):346-50.

PMID: 11220316

Abstract:

The synthesis of a beta-cyclodextrin-silica normal-phase (NP)-liquid chromatography (LC) stationary phase is reported. Silica gel was modified with (3-bromopropyl)trimethoxysilane to a 3-bromopropyl-silica that was reacted with beta-cyclodextrin, resulting in a beta-cyclodextrin-silica. To prove its usefulness in group-separation of organic nitrates among others, a mixture of three groups of organic nitrates was separated. The results are compared with those obtained on a nitrated polyol-silica that has recently been reported. The alkyl dinitrates exhibt higher retention relatively to alkyl mononitrates on the new phase. This allows to cut the LC fractions in a way that the alkyl mononitrates and phenylalkyl nitrates appear in one fraction and the dinitrates in a second one without any overlap of the two fractions.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP51826905	(3-Bromopropyl)trimethoxysilane		51826-90-5	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: