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New Steroidal Alkaloid and Furostanol Glycosides Isolated From Solanum Lyratum With Cytotoxicity

New Steroidal Alkaloid and Furostanol Glycosides Isolated From Solanum Lyratum With Cytotoxicity

Yun-Ling Xu, Jia Lv, Wei-Fang Wang, Yue Liu, Ya-Juan Xu, Tun-Hai Xu

Chin J Nat Med. 2018 Jul;16(7):499-504.

PMID: 30080648

Abstract:

Two previously undescribed steroidal compounds, 16, 23-epoxy-22, 26-epimino-cholest-22(N), 23, 25(26)-trien-3β-ol-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside (1) and 26-O-β-D-glucopyranosyl-(25R)-5α-furost-20(22)-en-3β, 26-diol (2), together with 7 known ones including 26-O-β-D-glucopyranosyl-(25R)-5, 20(22)-dien-furost-3β, 26-diol (3), (25R)-5-en-spirost-3β-ol-O-β-D-glucopyranosyl-(1→4)-[α-L-rhmanopyranosyl-(1→2)]-β-D-galactopyranoside (4), funkioside D (5), aspidistrin (6), tigogenin-3-O-β-D-lucotrioside (7), desglucolanatigonin II (8), and degalactotigonin (9), were isolated from Solanum lyratum Thunb. Their cytotoxic activities were tested in two cancer cell lines by MTT method. One of the steroidal glycosides (6) showed significant cytotoxic activity against gastric cancer SGC7901 and liver cancer BEL-7402 cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP39941510	Degalactotigonin		39941-51-0	Price

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