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New Δ-tocotrienol Derivatives From Colombian Propolis

New Δ-tocotrienol Derivatives From Colombian Propolis

Milena P Popova, Boryana S Trusheva, Paraskev T Nedialkov, Iva Tsvetkova, Dolly P Pardo-Mora, Hristo Najdenski, Orlando A Torres-García, José M Sforcin, Vassya S Bankova

Nat Prod Res. 2019 Apr 2;1-8.

PMID: 30938183

Abstract:

Two new δ-tocotrienol derivatives with oxidized terminal chain: 5,6-dioxo-garcinoic acid (trans-13'-carboxy-5,6-dioxo-δ-tocotrienol) (2) and 5-hydroxy-8b-oxo garcinoic acid (trans-13'-carboxy-5-hydroxy-8b-oxo-δ-tocotrienol) (3), together with one known derivative garcinoic acid (trans-13'-carboxy-δ-tocotrienol) (1) were isolated from a Colombian propolis. Garcinoic acid was found as a propolis constituent for the first time. The isolated compounds and crude ethanolic extract demonstrated high antimicrobial activity against Staphylococcus aureus and Candida albicans (MICs range: 10-39 μg/ml) as well as promising antioxidant potential in DPPH assay. Compound 3 displayed highest radical scavenging activity, even higher than that of dl-α-tocopherol, used as a positive control.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP25612593	δ-Tocotrienol		25612-59-3	Price

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