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New Trisulfated Steroids From the Vietnamese Marine Sponge

New Trisulfated Steroids From the Vietnamese Marine Sponge

Kseniya M Tabakmakher, Tatyana N Makarieva, Vladimir A Denisenko, Roman S Popov, Pavel S Dmitrenok, Sergey A Dyshlovoy, Boris B Grebnev, Carsten Bokemeyer, Gunhild von Amsberg, Nguyen X Cuong

Mar Drugs. 2019 Jul 27;17(8):445.

PMID: 31357591

Abstract:

Seven new unusual polysulfated steroids-topsentiasterol sulfate G (1), topsentiasterol sulfate I (2), topsentiasterol sulfate H (3), bromotopsentiasterol sulfate D (4), dichlorotopsentiasterol sulfate D (8), bromochlorotopsentiasterol sulfate D (9), and 4β-hydroxyhalistanol sulfate C (10), as well as three previously described-topsentiasterol sulfate D (7), chlorotopsentiasterol sulfate D (5) and iodotopsentiasterol sulfate D (6) have been isolated from the marine sponge Halichondria vansoesti. Structures of these compounds were determined by detailed analysis of 1D- and 2D-NMR and HRESIMS data, as well as chemical transformations. The effects of the compounds on human prostate cancer cells PC-3 and 22Rv1 were investigated.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42410311	Ammonium-15N2,d8 sulfate			Price

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