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New Water Soluble Glycosides of 11-keto-β-boswellic Acid: A Paradigm

New Water Soluble Glycosides of 11-keto-β-boswellic Acid: A Paradigm

B N Manjunath, Suvarna Shenvi, A Raja, G Chandrasekara Reddy

Nat Prod Res. 2018 Jan;32(2):154-161.

PMID: 28627258

Abstract:

Though several glycosides of various triterpenes are known, but surprisingly no boswellic acid glycosides are reported so far. With a view to make water soluble boswellic acids, prepared glycosides of 11-keto boswellic acid for the first time. Naturally occurring boswellic acids which are anti-inflammatory agents are lipophylic in nature and thus, become a limiting factor in terms of their bioavailability. Among boswellic acids, 11-keto-β-boswellic acid is found to exhibit superior biological activity and hence successfully prepared its glucosyl and maltosyl derivatives viz., 11-keto-β-boswellic acid-24-O-β-D-glucopyranoside (9) and 11-keto-β-boswellic acid-24-O-α-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside (15) which are water soluble. Both these compounds are soluble in water to the extent of 10% (w/w) which is very significant.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP631696	β-Boswellic acid		631-69-6	Price

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