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NHC-copper-thiophene-2-carboxylate Complex for the Hydroboration of Terminal Alkynes

Won Jun Jang, Byung-Nam Kang, Ji Hun Lee, Yoon Mi Choi, Chong-Hyeak Kim, Jaesook Yun

Org Biomol Chem. 2019 May 29;17(21):5249-5252.

PMID: 31089637

Abstract:

An air-stable N-heterocyclic carbene-copper thiophene-2-carboxylate (CuTC) complex has been prepared for the stereoselective hydroboration of terminal alkynes using pinacolborane (HBpin) or 1,8-naphthalenediaminatoborane (HBdan). The newly synthesized complex can be directly activated by hydroboranes without a cocatalyst such as a base, and exhibits high reactivity for the hydroboration of alkynes under mild conditions. A gram-scale hydroboration of terminal phenylacetylene demonstrated the applicability of the copper complex for the preparation of alkenyl boronates.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP420089516 Thiophene-2 Thiophene-2 420089-51-6 Price
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