Home
Resources
Publications
Niacinamide - Mechanisms of Action and Its Topical Use in Dermatology

Niacinamide - Mechanisms of Action and Its Topical Use in Dermatology

Johannes Wohlrab, Daniela Kreft

Skin Pharmacol Physiol. 2014;27(6):311-5.

PMID: 24993939

Abstract:

Niacinamide, an amide of vitamin B3 (niacin), is a hydrophilic endogenous substance. Its effects after epicutaneous application have long been described in the literature. Given a sufficient bioavailability, niacinamide has antipruritic, antimicrobial, vasoactive, photo-protective, sebostatic and lightening effects depending on its concentration. Within a complex metabolic system niacinamide controls the NFκB-mediated transcription of signalling molecules by inhibiting the nuclear poly (ADP-ribose) polymerase-1 (PARP-1). Niacinamide is a well-tolerated and safe substance often used in cosmetics. Clinical data for its therapeutic use in various dermatoses can increasingly be found in the literature. Although the existing data are not sufficient for a scientifically founded evaluation, it can be stated that the use of niacinamide in galenic preparations for epicutaneous application offers most interesting prospects.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP98920-B	Niacinamide		98-92-0	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: