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Nifekalant Hydrochloride Suppresses Severe Electrical Storm in Patients With Malignant Ventricular Tachyarrhythmias

Nifekalant Hydrochloride Suppresses Severe Electrical Storm in Patients With Malignant Ventricular Tachyarrhythmias

Takashi Washizuka, Masaomi Chinushi, Hiroshi Watanabe, Yukio Hosaka, Satoru Komura, Hirotaka Sugiura, Takashi Hirono, Hiroshi Furushima, Yasutaka Tanabe, Yoshifusa Aizawa

Circ J. 2005 Dec;69(12):1508-13.

PMID: 16308500

Abstract:

Background:
Some patients with an implantable cardioverter-defibrillator (ICD) suffer from burst of inappropriate multiple discharges (severe electrical storm), and because the current therapeutic options are limited, the effect of nifekalant hydrochloride, a new class III drug, on severe electrical storm was investigated in the present study.
Methods and results:
Ninety-one consecutive patients treated with ICD were included in the study (M 70; mean age 58 years; left ventricular ejection fraction 45+/-15%). Severe electrical storm was defined as more than 10 ICD discharges within 1 h. During a mean follow-up period of 30+/-13 months, 41/91 (45%) patients had appropriate ICD therapy for arrhythmias and severe electrical storm occurred in 11 of them (12%) at 20+/-18 months after ICD implantation. The mean number of ICD discharges/h during severe electrical storm was 18+/-12. In 4 of 10 patients, severe electrical storm was successfully suppressed by a combination of deep sedation and beta-blocking agent; 6 other patients were refractory to this treatment, but severe electrical storm was successfully suppressed by intravenous administration of nifekalant hydrochloride with no adverse effects.
Conclusions:
Nifekalant hydrochloride is an effective and safe treatment for severe electrical storm.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP130656518	Nifekalant hydrochloride		130656-51-8	Price

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