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Nine New Gingerols From the Rhizoma of Zingiber Officinale and Their Cytotoxic Activities

Nine New Gingerols From the Rhizoma of Zingiber Officinale and Their Cytotoxic Activities

Zezhi Li, Yanzhi Wang, MeiLing Gao, Wanhua Cui, Mengnan Zeng, Yongxian Cheng, Juan Li

Molecules. 2018 Feb 2;23(2):315.

PMID: 29393873

Abstract:

Nine new gingerols, including three 6-oxo-shogaol derivatives [(Z)-6-oxo-[6]-shogaol (1), (Z)-6-oxo-[8]-shogaol (2), (Z)-6-oxo-[10]-shogaol (3)], one 6-oxoparadol derivative [6-oxo-[6]-paradol (4)], one isoshogaol derivative [(E)-[4]-isoshogaol (5)], and four paradoldiene derivatives [(4E,6Z)-[4]-paradoldiene (8), (4E,6E)-[6]-paradoldiene (9), (4E,6E)-[8]-paradoldiene (10), (4E,6Z)-[8]-paradoldiene (11)], together with eight known analogues, were isolated from the rhizoma of Zingiber officinale. Their structures were elucidated on the basis of spectroscopic data. It was noted that the isolation of 6-oxo-shogaol derivatives represents the first report of gingerols containing one 1,4-enedione motif. Their structures were elucidated on the basis of spectroscopic and HRESIMS data. All the new compounds were evaluated for their cytotoxic activities against human cancer cells (MCF-7, HepG-2, KYSE-150).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP36700455	8-Shogaol		36700-45-5	Price

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