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Nine-step Total Synthesis of (-)-Strychnofoline

Nine-step Total Synthesis of (-)-Strychnofoline

Qingzhen Yu, Pan Guo, Jie Jian, Yuye Chen, Jing Xu

Chem Commun (Camb). 2018 Jan 25;54(9):1125-1128.

PMID: 29334094

Abstract:

Strychnofoline is a Strychnos alkaloid that has unique spirooxindole architecture and possesses important anticancer activity. Here, we have, for the first time, reported the enantioselective synthesis of strychnofoline proceeding in only nine steps from commercially available 6-methoxytryptamine. The efficiency of the synthesis derives from the use of two sequential transformation steps in the catalytic asymmetric construction of the spiro[pyrrolidine-3,3'-oxindole] motif in a facile manner. Our route is amenable to the synthesis of other natural and synthetic analogs of bioactive spirooxindole alkaloids to access their therapeutic potential.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3610364	6-Methoxytryptamine		3610-36-4	Price

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